How to detect magnetically labeled cells using magnetoelectric sensorsWednesday (07.06.2017) 20:27 - 20:30 Förde I Part of:
The detection of magnetically labeled cells has been of great interest in recent years and holds significant possibilities in the field of biomedical sciences for the nondestructive and non-invasive imaging of cells in 3D scaffolds. Here, a new detection method using magnetoelectric (ME) sensors is introduced where, similar to magnetic particle imaging (MPI), the nonlinear magnetization behavior of magnetic particle ensembles is used to detect higher harmonic excitations. These ME sensors, consisting of magnetostrictive and piezoelectric layers on a cantilever, show very high sensitivity anisotropy and sharp mechanical resonance, which leads to selective signal acquisition with regard to spatial orientation and excitation frequency. Using such inherent features of the sensor and the nonlinear magnetization behavior of nanoparticles, the objective is to detect and locate cells by scanning over the sample with the detector while applying a homogeneous alternating magnetic field. To achieve this objective, we formulate the restrictions and necessities of the detection system and analyze them with regard to measureable fields, particle densities, external magnetic fields, excitation frequencies and sensor orientations.