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Invited Lecture

Biomimicry at the molecular level: Molecularly imprinted polymers as synthetic antibody mimics

Thursday (08.06.2017)
17:40 - 18:20 Förde II + III
Part of:
12:20 Invited Lecture Similarities and differences between magnetic hysteresis and hysteresis in phase transformations 0 Richard James
13:00 Invited Lecture Discovery and Design of Multifunctional Materials using Combinatorial and High-Throughput Experimentation 1 Prof. Dr. Alfred Ludwig
15:10 Invited Lecture Tuning Mechanical Properties of Spider Cuticle by its Composition and by Structural Gradients 0 Dr. Yael Politi
15:50 Invited Lecture Surfaces and Gels for controlling Calcium Phosphate Deposition 0 Prof. Dr. Andreas Taubert
17:40 Invited Lecture Probing the Structure and Dynamic Behaviors of Ferroelectrics by Electron Microscopy with Atomic Resolution in Real Time 0 Prof. Xiaoqing Pan
18:20 Invited Lecture Magnetoelectric Composites for Energy Harvesting 1 Robert E. Hord, Jr. Professor Shashank Priya
19:40 Invited Lecture Declamping in Lead Magnesium Niobate – Lead Titanate Films 1 Prof. Susan Trolier-McKinstry
20:20 Invited Lecture Integrated Magnetics and Multiferroics for Compact and Power Efficient Sensing, Power, RF, Microwave and mm-Wave Electronics 0 Prof. Nian X. Sun
21:00 Invited Lecture From Maxwell’s displacement current to nanogenerator driven self-powered systems and blue energy 0 Prof. Zhong Lin Wang
21:40 Invited Lecture Magnetoelectric Composites: from Sensors to Sensor Systems 0 Prof. Dr.-Ing. Gerhard Schmidt
22:20 Invited Lecture Metal–insulator transition in vanadium oxides films and its applications 1 Dr. Keisuke Shibuya
00:20 Invited Lecture In operando photoemission spectroscopy of PMN-PT interfaces 0 Prof. Dr. Kai Rossnagel
08:30 Invited Lecture Titanium-Tantalum High Temperature Shape Memory Spring Actuators 1 Prof. Dr. Gunther Eggeler
09:10 Invited Lecture Vortex-antivortex topological structures in multiferroic tunnel junctions 1 Dr. Ana Sanchez
09:50 Invited Lecture Artificial Ferroic Systems 1 Prof. Laura Heyderman
17:40 Invited Lecture Biomimicry at the molecular level: Molecularly imprinted polymers as synthetic antibody mimics 0 Karsten Haupt
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Biomimicry is the general term covering any approach aimed at reproducing artificially essential properties of one or more biological systems. This is done in order to exploit natural mechanisms or materials for direct applications in different technological domains. One of the main application areas of biomimicry is materials science. At the molecular level, molecularly imprinted polymers (MIPs) are an example, mimicking molecular recognition phenomena.

MIPs are synthetic antibody mimics that specifically recognize molecular targets. They are highly cross-linked polymers that are synthesized through the polymerization of monomers bearing suitable functional groups, in the presence of the target molecule acting as a molecular template. This templating induces three-dimensional binding sites in the cross-linked polymer network that are complementary to the template in terms of size, shape and chemical functionality. Thus, these so-called 'plastic antibodies' can recognize and bind their targets with an affinity and selectivity similar to biological antibodies.

We present new approaches allowing for the synthesis of MIP by chemically and spatially controlled radical polymerization. This allows for example to obtain protein-size, soluble MIP nanogels with a homogeneous size distribution. They show specific binding of their targets, small organic molecules or proteins, with a nanomolar affinity and a good selectivity. Other examples are organic-inorganic nanocomposites. Since MIPs are compatible with standard micro and nanofabrication techniques, they can also be obtained in any other physical form, and at the same time interfaced with other materials. The use of these functional nanomaterials for affinity separation, biosensing, bioimaging and theranostics, and other applications will be discussed.

Karsten Haupt
Université de Technologie de Compi?gne